Azithromycin (Oral Route) Proper Use (2024)

Proper Use

Drug information provided by: Merative, Micromedex®

Take this medicine only as directed by your doctor. Do not take more of it, do not take it more often, and do not take it for a longer time than your doctor ordered.

This medicine comes with a patient information leaflet. Read and follow the instructions carefully. Ask your doctor if you have any questions.

You may take Zithromax® oral liquid or tablets with or without food.

Shake well the bottle of Zithromax® oral liquid before each use. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Measure the Zmax® extended-release oral suspension with a marked measuring spoon, syringe, or cup. You or your child must take this medicine within 12 hours after it has been mixed with water. It is best to take the Zmax® extended-release oral suspension on an empty stomach or at least 1 hour before or 2 hours after a meal. If your child does not use all of the medicine in the bottle, throw it away after you give the dose.

If you or your child vomits within one hour of taking the Zmax® extended-release oral suspension, call your doctor right away to see if more medicine is needed.

Keep using this medicine for the full treatment time, even if you or your child feel better after the first few doses. Your infection may not clear up if you stop using the medicine too soon.

If you are taking aluminum or magnesium-containing antacids, do not take them at the same time that you take Zithromax®. These medicines may keep azithromycin from working properly. However, you can take antacids with Zmax®.

Dosing

The dose of this medicine will be different for different patients. Follow your doctor's orders or the directions on the label. The following information includes only the average doses of this medicine. If your dose is different, do not change it unless your doctor tells you to do so.

The amount of medicine that you take depends on the strength of the medicine. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine.

  • For oral dosage form (extended-release suspension):
    • For treatment of pneumonia:
      • Adults—2 grams (g) once as a single dose.
      • Children weighing 34 kilograms (kg) or more—Dose is based on body weight and must be determined by your doctor. The dose is usually 2 grams once a day, taken as a single dose.
      • Children 6 months of age and older weighing less than 34 kg—Dose is based on body weight and must be determined by your doctor. The dose is usually 60 milligrams (mg) per kilogram (kg) of body weight once a day, taken as a single dose.
    • For treatment of sinusitis:
      • Adults—2 grams (g) once a day as a single dose.
      • Children—Use and dose must be determined by your doctor.
  • For oral dosage forms (suspension or tablets):
    • For treatment of infections:
      • Adults—500 to 2000 milligrams (mg) once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 250 to 500 mg once a day for several days.
      • Children 6 months of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 10 to 30 milligrams (mg) per kilogram (kg) of body weight once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 5 to 10 mg per kg of body weight once a day for several days.
      • Children younger than 6 months of age—Use and dose must be determined by your doctor.
    • For treatment of pharyngitis or tonsillitis:
      • Adults—500 milligrams (mg) on Day 1 (the first day), taken as a single dose. Then, 250 mg on Day 2 through Day 5.
      • Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 12 milligrams (mg) per kilogram (kg) of body weight once a day for 5 days.
      • Children younger than 2 years of age—Use and dose must be determined by your doctor.

Missed Dose

If you miss a dose of this medicine, take it as soon as possible. However, if it is almost time for your next dose, skip the missed dose and go back to your regular dosing schedule. Do not double doses.

Storage

Keep out of the reach of children.

Do not keep outdated medicine or medicine no longer needed.

Ask your healthcare professional how you should dispose of any medicine you do not use.

Store the medicine in a closed container at room temperature, away from heat, moisture, and direct light. Keep from freezing.

Do not refrigerate or freeze the Zmax® extended-release oral suspension. After water has been added to the powder, use the dose within 12 hours and throw away any unused liquid after your dose.

You may store the Zithromax® oral liquid at room temperature or in the refrigerator. Do not freeze the bottle. Do not keep the oral liquid for more than 10 days. Throw away any unused liquid after all doses are completed.

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  • Before Using
  • Precautions

Portions of this document last updated: June 01, 2024

Copyright: © Merative US L.P. 1973, 2024. All rights reserved. Information is for End User's use only and may not be sold, redistributed or otherwise used for commercial purposes.

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Azithromycin (Oral Route) Proper Use (2024)

FAQs

Azithromycin (Oral Route) Proper Use? ›

For oral dosage forms (suspension or tablets): For treatment of infections: Adults—500 to 2000 milligrams (mg) once a day, taken as a single dose. Depending on the type of infection, this may be followed with doses of 250 to 500 mg once a day for several days.

What is the proper way to take azithromycin? ›

You'll usually take azithromycin once a day. Try to take your medicine at the same time each day. Swallow tablets and capsules whole with a drink of water. If you are taking azithromycin capsules, take them at least 1 hour before food or 2 hours after eating.

What is the route of administration for azithromycin? ›

Azithromycin is available for both oral and parenteral (intravenous) administration. The extended-release formulation of azithromycin has been discontinued.

Can you give azithromycin orally? ›

You may take Zithromax® oral liquid or tablets with or without food. Shake well the bottle of Zithromax® oral liquid before each use. Measure your dose correctly with a marked measuring spoon, oral syringe, or medicine cup. The average household teaspoon may not hold the right amount of liquid.

Why is azithromycin no longer recommended? ›

Azithromycin, a commonly prescribed antibiotic for common infections since the early 1990s, is becoming less effective because of growing antimicrobial resistance.

What not to do when taking azithromycin? ›

Azithromycin can affect your heartbeat, so it's best not to take it with other medicines that have the same side effect. Tell your doctor if you're taking medicines that can affect your heartbeat, including: any medicines for an irregular heartbeat (arrhythmia), such as amiodarone or sotalol.

Why should azithromycin be taken on an empty stomach? ›

You can take azithromycin with or without food. Food doesn't change its effectiveness. But if you experience side effects like upset stomach or diarrhea after taking a dose, taking azithromycin with food with the next dose may help.

How do you use azithromycin oral suspension? ›

For the 1 gram single dose packet: This medication can be taken with food or on an empty stomach. Empty the contents of a single dose packet into two ounces of water (about one quarter of a full glass). Mix and drink all the mixture at once.

What is the rout of azithromycin? ›

Adults—500 milligrams (mg) on Day 1 (the first day), taken as a single dose. Then, 250 mg on Day 2 through Day 5. Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 12 milligrams (mg) per kilogram (kg) of body weight once a day for 5 days.

Is azithromycin oral or IV? ›

For the treatment of adult patients with PID due to the indicated organisms, the recommended dose of IV azithromycin is 500 mg as a single daily dose by the IV route for 1 or 2 days. IV therapy should be followed by oral azithromycin at a single daily dose of 250 mg to complete a 7-day course of therapy.

How long does oral azithromycin take to work? ›

Azithromycin typically begins working rather quickly, but it can take a few hours to reach peak concentrations in your body. Many people find their symptoms start to resolve within a few days of beginning treatment. However, everyone is different.

Do I swallow azithromycin? ›

Azithromycin is available on prescription as capsules, tablets and a liquid that you swallow. It can also be given by injection, but this is usually only done in hospital.

Is it OK to chew azithromycin? ›

Azithromycin tablets and liquid can be taken with or without food but the capsules should be taken an hour before food or two hours after food. Tablets and capsules should be swallowed with a glass of water or juice. Your child should not chew the tablets or capsules.

Why is azithromycin high risk? ›

Also, in vitro, azithromycin shows only lim- ited blockade of the potassium channel hERG. This channel is critically involved in cardio- myocyte repolarization, and if it is blocked or otherwise malfunctioning, the result can be a prolonged QT interval, ventricular arrhyth- mias, and even sudden cardiac death.

Is azithromycin a bad antibiotic? ›

This medicine can cause changes in heart rhythms, including QT prolongation. It may change the way your heart beats and cause fainting or serious side effects in some patients.

Why is azithromycin 500 given for 3 days only? ›

The practice of prescribing azithromycin for three days is based on its unique pharmaco*kinetic properties, efficacy, and safety. Short-term treatment with azithromycin provides multiple benefits, including improved compliance, reduced antibiotic resistance, and convenience for patients.

What foods should you avoid while taking azithromycin? ›

Stick to simple meals and do not eat rich or spicy food while you're taking this medicine. Drink lots of fluids such as water or squash to avoid dehydration. Signs of dehydration include peeing less than usual or having dark, strong-smelling pee.

Do you take 2 azithromycin on the first day? ›

Adults—500 milligrams (mg) on Day 1 (the first day), taken as a single dose. Then, 250 mg on Day 2 through Day 5. Children 2 years of age and older—Dose is based on body weight and must be determined by your doctor. The dose is usually 12 milligrams (mg) per kilogram (kg) of body weight once a day for 5 days.

How long does it take for azithromycin to start helping? ›

How long does it take to work? The medication will start working straight away. However, it is important to take the whole course of medicine that has been prescribed. This is because it takes a while for the antibiotics you have taken to kill the bacteria causing your infection.

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